It is unclear whether her extreme focus on “her mission” was a manipulative effort or actual self-denial; her actions could support both positions.
There are many instances of Holmes legally pursuing whistleblowers and publicly attacking external detractors - essentially anyone threatening the positive perception of Theranos. This seems to support a more manipulative scenario.
Within the company, parallels are found where Holmes would physically give employees a cold shoulder for lack of enthusiasm or lambasting them for perceived lapses in loyalty. These internal episodes point towards self-denial - shutting out anything that conflicts with her perception of reality.
To me, it’s inconclusive but the latter would be a more interesting situation.